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A drug candidate must first be proven safe before entering clinical trials The current state of screening methods for drug discovery is still riddled with several inefficiencies Good laboratory practices (glp) is the managerial quality control system that covers entire organisation and testing procedures to ensure quality, uniformity, consistency, reliability and reproducibility.
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This requires a higher throughput type of assay Here we describe a new detection platform suitable for high throughput screening (hts) applications using a fluorescence polarization based herg inhibition assay as a model. It has the characteristics of high sensitivity, widely effective linear range, high homogeneity, high reproducibility, minimal matrix effect, good stability and high detection throughput. Toxicology studies form the cornerstone of preclinical drug development, enabling the safe progression of investigational drugs to human clinical trials
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